| Registro completo |
| Provedor de dados: |
BJMBR
|
| País: |
Brazil
|
| Título: |
Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy models
|
| Autores: |
Del-Bel,E.A.
Oliveira,P.R.
Oliveira,J.A.C.
Mishra,P.K.
Jobe,P.C.
Garcia-Cairasco,N.
|
| Data: |
1997-08-01
|
| Ano: |
1997
|
| Palavras-chave: |
Experimental epilepsy
Seizures
Forebrain
Brainstem
Pilocarpine
Pentylenetetrazol
Audiogenic seizures
Genetically epilepsy-prone rats
GEPR
Nitric oxide
|
| Resumo: |
The effect of acute (120 mg/kg) and chronic (25 mg/kg, twice a day, for 4 days) intraperitonial injection of the nitric oxide (NO) synthase (NOS) inhibitor NG-nitro-L-arginine (L-NOARG) was evaluated on seizure induction by drugs such as pilocarpine and pentylenetetrazole (PTZ) and by sound stimulation of audiogenic seizure-resistant (R) and audiogenic seizure-susceptible (S) rats. Seizures were elicited by a subconvulsant dose of pilocarpine (100 mg/kg) only after NOS inhibition. NOS inhibition also simultaneously potentiated the severity of PTZ-induced limbic seizures (60 mg/kg) and protected against PTZ-induced tonic seizures (80 mg/kg). The audiogenic seizure susceptibility of S or R rats did not change after similar treatments. In conclusion, proconvulsant effects of NOS inhibition are suggested to occur in the pilocarpine model and in the limbic components of PTZ-induced seizures, while an anticonvulsant role is suggested for the tonic seizures induced by higher doses of PTZ, revealing inhibitor-specific interactions with convulsant dose and also confirming the hypothesis that the effects of NOS inhibitors vary with the model of seizure
|
| Tipo: |
Info:eu-repo/semantics/article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000800010
|
| Editor: |
Associação Brasileira de Divulgação Científica
|
| Relação: |
10.1590/S0100-879X1997000800010
|
| Formato: |
text/html
|
| Fonte: |
Brazilian Journal of Medical and Biological Research v.30 n.8 1997
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
